Thought Leaders in Antibody Libraries

At Specifica we live Antibody Libraries. Forever innovating, we have generated over 100 naive individual Libraries using different scaffolds, formats, variable gene sources and diversity sets. We learn from failure – a better teacher than success. We understand the complexities of Antibody Library construction. By using cutting edge next generation sequencing (NGS) for quality control at all steps of construction and validation we are able to count, rather than estimate, the number of different antibodies in each Specifica library, so ensuring our high diversity standards.

Whether a Generation 2 or a Generation 3 Library, high guaranteed diversities mean more antibodies, recognizing more epitopes, with higher affinities, against more targets. Libraries are usually provided in phage display formats, and, except for Fab, can also be supplied in the yeast display format.

Exclusively yours

Donors providing lymphocytes to create Specifica naive libraries are only used to build libraries for you, ensuring each library is unique and exclusive to you. Specifica’s Generation 2 Libraries are natural antibody libraries created from the rearranged antibody genes found in natural B lymphocytes, while Generation 3 Libraries are based on well-behaved therapeutic scaffolds with quality built in by design, rather than by testing.

In addition to in-house designs, we also collaborate closely with you to create custom libraries in which essential elements are optimized according to your needs.

 When you adopt the Specifica Platform we provide you with phage stocks of your own exclusive Generation 3 Antibody library to get you started; enough bacterial stocks to keep you going for decades; vectors; comprehensive manuals including phage and yeast display selection, straightforward affinity maturation, and scFv to IgG reformatting. Full training at Specifica will empower you to generate the best therapeutic antibodies in your labs.

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