Monoclonal antibody
reagents
Specifica is applying its proven platform for antibody discovery to generate recombinant monoclonal antibody reagents. Our in vitro display approach eliminates the need for immunization, addressing animal welfare concerns and insufficient quantities of antigen. Delivery of recombinant sequences ensures higher specificity and reproducibility than animal-based methods, as well as the ability to easily engineer these reagents.
Our Process
Specifica’s team brings a depth of
knowledge and a primary focus on
generating antibodies.
Choose a leading provider of antibody
drug discovery to identify and validate
your drug target.
Quality control of the antigen
1 Week
Rounds of phage/yeast display
1-3 Weeks
NGS-based identification of leads
2 Weeks
Ab production and purification
3 Weeks
QC and delivery
1 Week
Your Deliverables
The antibody sequence for future needs
Sequence also retained at Specifica
Ready-to-use custom antibody reagents
Either bulk or aliquots of purified antibody
Anti-Idiotypes (anti-Ids) for Drug Discovery
- Highest-quality recombinant antibodies using Specifica’s proven platform for antibody discovery
- Fully engineerable – species-specific Fc, isotype and subclass, etc.
- Ideal for capture and/or detection reagents in PK/PD and ADA assays
- Specificity unmatched by immunization or hybridomas
- Highly reproducible for efficient transition to the next phase of research
- Scalable solutions enable rapid production when desired
- Consistent performance lot-to-lot, removing the ‘guess work’ of immunization approaches
- Deliverables include purified protein and antibody sequences
What are the benefits of the Gen 3 technology for tool reagents?
Sequence-defined antibodies are fully reproducible and can be engineered for species-specific Fc, isotype, or subclass needs—streamlining method development and secondary reagent selection. As monoclonals, they offer higher specificity and eliminate lot-to-lot variability.
How fast is the turnaround compared to immunizations?
Turnaround time of weeks, versus months for animal; additionally, more humane than animal studies, which require ongoing euthanasia of host animals (1,2).
References:
2 https://www.nal.usda.gov/animal-health-and-welfare/animal-use-alternatives