Antibody Libraries

Bring antibody discovery in-house with an exclusive antibody platform built specifically for your organization

Specifica builds and transfers custom Generation 3 antibody libraries to support internal research and development needs at your lab, facilitating antibody discovery that meets your needs at your pace. Each library combines highly developable therapeutic scaffolds, validated natural diversity, and a unique client-exclusive HCDR3 repertoire to create a discovery platform optimized for affinity, diversity, developability and speed. Unlike shared libraries, each platform is built exclusively for a single customer, helping maximize epitope coverage while minimizing the risk of overlapping discoveries with competitors. Our libraries don't just screen for antibodies that bind well. Gen 3 libraries are designed to produce antibodies with drug-like characteristics, reduce the amount of downstream engineering.

Specifica Antibody Libraries Deliver:

- True platform ownership
  - Conduct antibody discovery internally using your team and with full control of your programs
- Exclusivity
  
  Each platform is constructed using a unique, client-specific HCDR3 donor used only for your library.
- No royalties or milestone fees
  - Straightforward business terms without ongoing payments supports long-term innovation in your lab
- Proven results
  - Nine of the top 20 pharma companies own a Specifica antibody library. With 30 custom libraries and counting, Specifica facilitates discovery at traditional pharma companies, emerging biopharma, academic research centers and AI companies.

Discuss an Exclusive Library

~10²⁶ possible combinations

>10¹⁰ transformants

Our approach delivers a one-of-a-kind library and virtually eliminates the risk of pursuing an antibody already identified by a competitor. The importance of this became clear when Genentech and Human Genome Sciences independently discovered identical antibodies against the same target from the same phage display library, leading to a patent dispute. The rise of next-generation sequencing has only heightened this risk.

Available formats include VHH, scFv and Fab. Our scFv and Fab libraries are also available with common light chains. We typically provide 4 sub-libraries, but can provide just a single sub-library based on your project.

Exclusive library

Built using a unique HDCR3 donor for maximum diversity — billions of antibodies for the most challenging targets — with built-in developability. You receive 4 sub-libraries representing different V families.

Technology transfer

• Library assets

• NGS data

• Vectors

• Protocols

• Training

• Discovery workflows

Affinity maturation module

Your library platform includes our affinity maturation module, delivering up to 1000-fold affinity improvement.

Scientific support

Your team will receive full training at Specifica's lab in Santa Fe, New Mexico, from the scientists who built the platform.

Specifica libraries are ideal for organizations that want to:

Build internal antibody discovery capabilities
Reduce dependence on outsourcing
Protect proprietary discovery strategies
Accelerate biologics pipelines

Royalty-free terms

Specifica doesn’t charge royalties, milestone-based fees or “research” fees for our work. We value transparency and clarity in our scientific and business and practices. You’ll know costs upfront before we start, and we won’t ask you to share your intellectual property or pay us licensing fees in perpetuity. Your molecules are yours; we won’t ask you to report back to us or allow us to conduct any audits.

Get In Touch

Contact Us

If you would like to get in touch with us please use the contact form or email address below.

Email

info-specifica@iqvia.com