Affinity Maturation & Antibody Optimization

Improve affinity without losing the properties that matter

Advance promising antibodies with an affinity maturation and optimization strategy designed around your molecule and program goals. Specifica applies controlled library design and in vitro selection to improve binding performance while maintaining focus on specificity and developability.

- - 10- to 1,000-fold improvement in affinity while preserving the epitope-binding characteristics
  - Controlled selection to improve binding while preserving or improving developability
  - A focused path for existing antibody leads

Our platform improves antibodies from both in vitro and in vivo platforms that have the desired biological activity but need additional optimization. Our tailored approach is optimized for your molecule. Whether you need better affinity or developability improvements such as stability and solubility, our iterative process can help you advance your lead candidates.

Optimize more than affinity

Selection strategies can incorporate properties such as specificity, cross-reactivity, ligand blocking, pH-dependent binding and developability considerations. Our approach helps identify improved variants that are better aligned with downstream development needs—not simply tighter binders.

A controlled, iterative approach

Define the optimization objective
- Align on affinity, specificity, developability and functional requirements

Build focused maturation libraries
- Introduce targeted diversity while retaining critical binding features.
Select and characterize improved variants
- Apply in vitro selection and screening against the desired profile.