Specifica Webinars

Posted webinars are based on the talks and courses indicated.

The Greatest Competition in Antibody History: A Naïve Library Directly Delivering Antibodies As Potent As Immune Sources

The SARS-CoV-2 pandemic has resulted in an extraordinary worldwide unplanned experiment, in which numerous scientific groups have generated antibodies against a single target: the CoV-2 spike antigen, allowing the comparison of different methods and derived antibodies. The most potent neutralizing antibodies have been generated from convalescent patients and immunized animals, with non-immune phage libraries usually yielding significantly less potent antibodies. Here we show it is possible to generate ultra-potent (IC50 <2ng/ml) human neutralizing antibodies directly from a novel naïve antibody library format with affinities, developability properties and neutralization activities comparable to the best from hyperimmune sources

May 12, 2021

Antibody discovery in the cloud: using NGS to expand the universe of selectable antibodies

The Specifica Generation 3 platform is able to generate 500-5000 different antibody clonotypes against targets of interest, with over 80% of selected antibodies having no measurable biophysical liabilities and 20% having subnanomolar affinities. The most common approach to selecting antibodies from display technologies involves low-throughput random colony screening. However, this misses many potential therapeutic leads, particularly when diversity is high. Specifica uses next generation sequencing (NGS) to build its libraries as well as characterize selection outputs. In order to fully exploit the universe of selectable antibodies, Specifica has developed a cloud-based software platform, designed exclusively for antibody engineers and bioinformaticians, to enable a streamlined identification of leads with broad epitope coverage. Application of this to selection outputs has increased the number of clonotype leads by five to ten fold over random colony screening, significantly expanding the explorable paratope spaces.

January 21, 2021

High Quality Antibodies Straight From Selections

Specifica’s Generation 3 Library Platform has quality built in by design. Developability, extremely high diversity, and the exclusion of sequence liabilities are intrinsic to the five sub-libraries making up the Platform, each of which is based on a therapeutic antibody scaffold chosen for its biophysical properties, lack of liabilities and germline gene variety.

December 14, 2020

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