Publications - Specifica Inc

Specifica publications, and relevant prior publications from Specifica scientists

Pandemic’s silver lining

Fortunato Ferrara,

Sara D’Angelo,

M. Frank Erasmus,

André A. Teixeira,

Camila Leal-Lopes,

Laura P. Spector,

Tom Pohl,

Adeline Fanni,

Simon Cocklin,

Andrew R. M. Bradbury,

2022 | mAbs

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Simultaneous affinity maturation and developability enhancement using natural liability-free CDRs

Andre Teixeira,

Sara D’Angelo,

M. Frank Erasmus,

Camila Leal-Lopes,

Fortunato Ferrara,

Laura Spector,

Leslie Naranjo,

Esteban Molina,

Tamara Max,

Ashley DeAguero,

Katherine Perea,

Shaun Stewart,

Rebecca Buonpane,

Horacio Nastri,

Andrew Bradbury,

2022 | mAbs

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A pandemic-enabled comparison of discovery platforms demonstrates a naive antibody library can match the best immune-sourced antibodies

Fortunato Ferrara,

M. Frank Erasmus,

Sara D’Angelo,

Camila Leal-Lopes,

Andre A. Teixeira,

Alok Choudhary,

William Honnen,

David Calianese,

Deli Huang,

Linghan Peng,

James E. Voss,

David Nemazee,

Dennis R. Burton,

Abraham Pinter,

Andrew R.M. Bradbury,

2022 | Nature Communications

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Drug-like antibodies with high affinity, diversity and developability directly from next-generation antibody libraries

Andre A. Teixeira,

M. Frank Erasmus,

Sara D’Angelo,

Leslie Naranjo,

Fortunato Ferrara,

Camila Leal-Lopes,

Oliver Durrant,

Cecile Galmiche,

Aleardo Morelli,

Anthony Scott-Tucker,

Andrew R.M. Bradbury,

2021 | mAbs

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Construction, characterization and crystal structure of a fluorescent single-chain Fv chimera

Nileena Velappan,

Devin Close,

Li-Wei Hung,

Leslie Naranjo,

Colin Hemez,

Natasha DeVore,

Donna McCullough,

Antonietta M. Lillo,

Geoffrey S. Waldo,

Andrew R.M. Bradbury,

2021 | peds

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A single donor is sufficient to produce a highly functional in vitro antibody library

M. Frank Erasmus,

Sara D’Angelo,

Fortunato Ferrara,

Leslie Naranjo,

Andre Teixeira,

Rebecca Buonpane,

Shaun M. Stewart,

Nastri G. Horacio,

Andrew R.M. Bradbury,

2021 | Communications Biology

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Selection and characterization of Fc epsilon R1 phospho-ITAM specific antibodies

Nileena Velappan,

Avnika Mahajan,

Leslie Naranjo,

Prianka Velappan,

Nasim Andrews,

Nick Tiee,

Subhendu Chakraborti,

Colin Hemez,

Tiziano Gaiotto,

Bridget Wilson,

Andrew Bradbury,

2019 | MAbs: 1-13

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Recombinant antibodies against mycolactone

Leslie Naranjo,

Fortunato Ferrara,

Nicolas Blanchard,

Caroline Demangel,

Sara D’Angelo,

M. Frank Erasmus,

André Teixeira,

Andrew Bradbury,

2019 | Toxins (Basel) 11(6)

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Rapid purification of billions of circulating CD19+ cells directly from leukophoresis samples

Fortunato Ferrara,

Martin Kolnik,

Sara D’Angelo,

M. Frank Erasmus,

André Teixeira,

Daniela Vorholt,

Andrew Bradbury,

2018 | N Biotechnol 46

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When monoclonal antibodies are not monospecific: hybridomas frequently express additional functional variable regions

Andrew Bradbury,

Nathan Trinklein,

Holger Thie,

Ian Wilkinson,

Atul Tandon,

Stephen Anderson,

Catherine Bladen,

Brittany Jones,

Shelly Force Aldred,

Marco Bestagno,

Oscar Burrone,

Jennifer Maynard,

Fortunato Ferrara,

James Trimmer,

Janina Görnemann,

Jacob Glanville,

Philipp Wolf,

Andre Frenzel,

Julin Wong,

Xin Yu Koh,

Hui-Yan Eng,

David Lane,

Marie-Paule Lefrance,

Mike Clark,

Stefan Dübel,

2018 | MAbs 10 1-19

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Selection of phage displayed accessible recombinant targeted antibodies (SPARTA): methodology and applications

Sara D’Angelo,

Fernanda Staquicini,

Fortunato Ferrara,

Daniela Staquicini,

Geetanjali Sharma,

Christy Tarleton,

Huynh Nguyen,

Leslie Naranjo,

Richard Sidan,

Wadih Arap,

Andrew Bradbury,

Renata Pasqualini,

2018 | JCI Insight 3(9)

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Many routes to an antibody heavy-chain CDR3: necessary, yet insufficient for specific binding

Sara D’Angelo,

Fortunato Ferrara,

Leslie Naranjo,

M. Frank Erasmus,

Peter Hraber,

Andrew Bradbury,

2018 | Frontiers in Immunology 9

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Selected Prior Publications

High-throughput screening of single-chain antibodies using multiplexed flow cytometry

J Ayriss,

T Woods,

P Pavlik,

Andrew Bradbury,

2007 | J Proteome Res 6

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Eliminating helper phage from phage display

L Chasteen,

J Ayriss,

P Pavlik,

Andrew Bradbury,

2006 | Nucleic acids research 34

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Using phage display to select antibodies recognizing post-translational modifications independently of sequence context

J W Kehoe,

2006 | Mol Cell Proteomics 5

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Characterizing monoclonal antibody epitopes by filtered gene fragment phage display

R Di Niro,

2005 | The Biochemical journal 388

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Recombinatorial cloning using heterologous lox sites

R W Siegel,

N Velappan,

P Pavlik,

L Chasteen,

Andrew Bradbury,

2004 | Genome Res 14

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Selecting open reading frames from DNA

P Zacchi,

D Sblattero,

F Florian,

R Marzari,

Andrew Bradbury,

2003 | Genome Research 13

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Antibodies in haystacks: how selection strategy influences the outcome of selection from molecular diversity libraries

J Lou,

2001 | Journal of immunological methods 253

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Exploiting recombination in single bacteria to make large phage antibody libraries

D Sblattero,

Andrew Bradbury,

2000 | Nat Biotechnol 18

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