Antibody Libraries
Bring antibody discovery in-house with an exclusive antibody platform built specifically for your organization
Specifica builds and transfers custom Generation 3 antibody libraries to support internal research and development needs at your lab, facilitating antibody discovery that meets your needs at your pace. Each library combines highly developable therapeutic scaffolds, validated natural diversity, and a unique client-exclusive HCDR3 repertoire to create a discovery platform optimized for affinity, diversity, developability, and speed. Unlike shared libraries, each platform is built exclusively for a single customer, helping maximize epitope coverage while minimizing the risk of overlapping discoveries with competitors.
The Specifica Difference
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True platform ownership
Conduct antibody discovery internally while maintaining full control of your programs
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Exclusivity
Client-specific diversity by using a unique donor source
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No royalties or milestone fees
Straightforward business terms designed to support long-term innovation
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Proven results
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Nine of the top 20 pharma companies have a custom Specifica antibody library. With 30 custom libraries and counting, Specifica supports discovery at large companies, emerging biopharma, academic and AI companies.
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Our approach virtually eliminates the risk of pursuing an antibody already identified by a competitor. The importance of this became clear when Genentech and Human Genome Sciences independently discovered identical antibodies against the same target from the same phage display library, leading to a patent dispute. The rise of next-generation sequencing has only heightened this risk.
Available formats include VHH, scFv and Fab. Our scFv and Fab libraries are also available with common light chains. We can build libraries across all formats or just a single sub-library.
| What's Included? | |||
| Exclusive Gen 3 Library | Technology transfer | Affinity Maturation Module | Scientific Support |
| Built specifically for your organization using unique HDCR3 diversity — billions of antibodies for the most challenging targets — with built-in developability. Each library is composed of four sub-libraries, expanding diversity and representing different V families. | • Library assets • Vectors • Protocols • Training • Discovery workflows |
Optimize antibodies discovered internally using the same platform. |
Full training at Specifica from the scientists who built the platform. |
Specifica libraries are ideal for organizations that want to:
- Build internal antibody discovery capabilities
- Reduce dependence on outsourcing
- Protect proprietary discovery strategies
- Accelerate biologics pipelines
Royalty-free terms
Specifica doesn’t charge royalties, milestone-based fees or “research” fees for our work. We value transparency and clarity in our scientific and business and practices. You’ll know costs upfront before we start, and we won’t ask you to share your intellectual property or pay us licensing fees in perpetuity. Your molecules are yours; we won’t ask you to report back to us or allow us to conduct any audits.
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